Endocrine Abstracts

The aim of the study was to determine the clinical, immunological and genetics markers of latent autoimmune diabetes of adults (LADA) in early terms of disease development.Materials and methods: Seventy-eight LADA patients (47 women, 31 men, age of manifestation 45.52±1.83 years, average age 49.37±1.17 years, insulindependence age 49.33±0.34 years with anti islet, GADA antibodies and low C-peptide levels) were enrolled. The GADA, IA2A and ...

The aim: To investigate the prevalence of subclinical late-onset hypogonadism (SLOH) in men with diabetes type 2 and relationship between testosterone concentrations and duration of diabetes.Material and methods: We investigated 114 men with DT 2 aged from 45–60 years (M±SD 54.0±4.63). Luteinizing hormone (LH), follicle-stimulating hormone (FSH), total testosterone (T), calculated free testosterone (cFT) and bioavailable testosterone (bT),...

Bile acids (BA) regulate glucose and lipid metabolism, provide bile flow, increase lipase activity by 10–15 times. With the development of inflammation, violations occur in the membrane proteins of glucose transporters.AimDetermine the total pool of bile acids in NAFLD with diabetes mellitus (DM) and impaired glucose tolerance (IGT). Determine the content of inflammation markers lipoprotein-associated phospholipase (Lp-PLA2), ...

Retinol binding protein (RBP) is an adipokine, related to insulin resistance (IR). Excess free fat acid reduces the binding of insulin by hepatocyte receptors and leads to hyperinsulinemia. RBP transport protein synthesized in hepatocytes and adipocytes. The level of RBP increases in patients with obesity, diabetes andnon-alcoholic fatty liver disease (NAFLD). It is positively correlated with the degree of severity of the inflammatory process and fibrosis. The RBP regulates th...

Purpose of researchTo determine the level of insulin content, the content of nitric oxide metabolites, Malondialdehyde, the activity of lipoprotein-associated phospholipase A2 (FLA2), in the blood serum of patients with NFLD with type II D and impaired glucose tolerance.Material and methodsThe study included 74 patients with non-alcoholic fatty liver disease. 30 of them have diabetes of the second type, and 3...

Given the significant correlation between the indices of lipid metabolism, liver dimensions, glycated hemoglobin and indicators cytolysis of hepatocytes identified a number of predictors that have had a significant influence on the formation of NAFLD. At a BMI above 26.5 kg/m2, the relative risk (RR) for BMI was 20.02 and was statistically significant (8.25÷48.61). When VLDL level above 0.6 mmol/l relative risk for NAFLD also was statistically significant (RR=2...

In late pregnancy, the hypothalamo-pituitary-adrenal (HPA) axis is less responsive to immune challenge(1). Circulating and brain levels of allopregnanolone (AP), a neuroactive steroid and allosteric enhancer at inhibitory GABAA receptors, increase during pregnancy(2) and AP treatment attenuates stress-induced HPA activity in male rats(3). Here we sought a role for AP in attenuated HPA axis responses to interleukin-1-beta (IL-1B) in pregnant rats. Conscious pregnant (day 21) an...

UNUSUAL PRESENTATION OF DIABETES FOOT ULCERAM Mousa, G Knight, S Muzulu, J R Rochester. Rotherham General Hospital, Moorgate Road, Rotherham S60 2UD.IntroductionPhalangeal metastases commonly display inflammatory symptoms that mimic an acute infection. We describe a rare case of bronchogenic carcinoma with metastases to the left 3rd and 4th toes, which presented as presumed diabetic foot ulceration.<p cla...

Introduction:The genetics of most cases of familial phaechromocytomas is unknown.Up to 50%of paragangliomas arefamilial and increased susceptibility is seen in SDHD and SDHC mutations.We report a family with a mutation in the SDHB gene .Case report: The index case, a 22 year old male was treated at the age of 10 years with extra adrenal phaeochromocytoma. Recently, he was found to have ...

The principal physiological effect of the anterior pituitary hormone prolactin is to stimulate milk production during lactation. However, recombinant mouse prolactin (PRL) has recently been shown to have an antidiuretic effect when the normal antidiuretic hormone, vasopressin, is either absent from the circulation or its secretion inhibited(1). The present study was designed to investigate whether this antidiuretic effect of prolactin was mediated by changes in the glomerular ...